Core signal
What: Cochrane rated the certainty of evidence for methylphenidate as "very low."
PRO Summary
How to read this card
Evidence scope
Who: Risk of bias, under-reporting of side effects, and study heterogeneity were the main reasons.
Use principle
Result: This means "hard to say with certainty," not "it doesn't work."
Evidence Reading
What to check when interpreting the evidence
Study typeType: SystematicReview
PopulationTarget: Children/adolescents with ADHD (multiple RCTs included)
EvidenceGrade: B
UseResult: This means "hard to say with certainty," not "it doesn't work."
Consultation Prep
Turn the card into questions before consultation
Don't just read the headline — check the reviewing organization and their criteria.
Record this as a question or context point before professional consultation.
Ask your doctor about the latest evidence.
Record this as a question or context point before professional consultation.
Limits
PRO use principles
Evidence scope
Limitations: Differences between Cochrane and NMA interpretations stem from methodological differences. Under-reporting of side effects is possible.
Hold individual application
Do not transfer group-level findings or review summaries directly to an individual case without considering family context, school context, comorbidity, and professional guidance.
Use principle
Disclaimer: This summary is for informational purposes only and does not direct medication use, discontinuation, or changes. Consult your physician.
Professional consultation
Diagnosis, treatment, medication, educational planning, and ADHD management should be discussed with qualified professionals.
Scope Note
Notice and limits
Limitations: Differences between Cochrane and NMA interpretations stem from methodological differences. Under-reporting of side effects is possible.
Disclaimer: This summary is for informational purposes only and does not direct medication use, discontinuation, or changes. Consult your physician.